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Article

UGT1A1 (TA)n genotype is not the major risk factor of cholelithiasis in sickle cell disease children.

European journal of haematology - 1 Mar 2017

Joly Philippe, Renoux Céline, Lacan Philippe, Bertrand Yves, Cannas Giovanna, Garnier Nathalie, Cuzzubbo Daniella, Kebaïli Kamila, Renard Cécile, Gauthier Alexandra, Pialoux Vincent, Martin Cyril, Romana Marc, Connes Philippe

Abstract excerpt

OBJECTIVES: Because of the increased hemolytic rate, a significant proportion of patients with sickle cell disease (SCD) are prone to develop cholelithiasis. The present study investigated the role of several genetic factors (UGT1A1 promoter (TA)n repeat polymorphism, alpha-globin status), hematological parameters, clinical severity, and hydroxyurea (HU) therapy on the occurrence of cholelithiasis in SCD....

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PMID: 27981643
DOI: 10.1111/ejh.12838

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SCD
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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