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Article

The effect of UGT1A1 promoter polymorphism in the development of hyperbilirubinemia and cholelithiasis in hemoglobinopathy patients.

PloS one - 1 Jan 2013

AlFadhli Suad, Al-Jafer Hassan, Hadi Mays, Al-Mutairi Mashael, Nizam Rasheeba

Abstract excerpt

Present study was aimed to explore the effect of (TA)n UGT1A1 gene promoter polymorphism on bilirubin metabolism, bilirubinaemia, predisposition to cholelithiasis and subsequent cholecystectomy, in Sickle-Cell Anemia (SCA) and beta-Thalasemia major (bTH) in Kuwaiti subjects compared to other population. This polymorphism was analyzed and correlated to total bilirubin and cholelithiasis in 270 age, gender,...

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Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bilirubin

Share to Cholelithiasis

Share to Glucuronosyltransferase

Share to Hemoglobinopathies

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Share to Promoter Regions, Genetic

Source

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Identifiers

PMID: 24204915
DOI: 10.1371/journal.pone.0077681
PMCID: PMC3813713

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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