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Article

UGT1A1 variation and gallstone formation in sickle cell disease.

Blood - 1 Feb 2005

Haverfield Eden V, McKenzie Colin A, Forrester Terrence, Bouzekri Nourdine, Harding Rosalind, Serjeant Graham, Walker Thomas, Peto Tim E A, Ward Ryk, Weatherall David J

Abstract excerpt

Pigment gallstones are a common clinical complication of sickle cell (SS) disease. Genetic variation in the promoter of uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) underlies Gilbert syndrome, a chronic form of unconjugated hyperbilirubinemia, and appears to be a risk factor for gallstone formation. We investigated the association between UGT1A1 (TA)(n) genotype, hyperbilirubinemia, and...

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Identifiers

PMID: 15388579
DOI: 10.1182/blood-2004-02-0521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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