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Article

UGT1A1 promoter polymorphisms and the development of hyperbilirubinemia and gallbladder disease in children with sickle cell anemia.

American journal of hematology - 1 Oct 2008

Carpenter Shannon L, Lieff Susan, Howard Thad A, Eggleston Barry, Ware Russell E

Abstract excerpt

Genetic modifiers contribute to phenotypic variability in patients with sickle cell anemia (SCA). The influence of the bilirubin UDP-glucuronosyltransferase (UGT) 1A1 (TA)(n)TAA promoter polymorphism on bilirubin levels and gallbladder disease in SCA was examined using prospectively collected data from the Cooperative Study of Sickle Cell Disease. A total of 324 children with HbSS (median age 6.9 years) had...

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PMID: 18756540
DOI: 10.1002/ajh.21264

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