UGT1A promoter polymorphisms influence bilirubin response to hydroxyurea therapy in sickle cell anemia.

doi:10.1067/mlc.2003.28

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Article

UGT1A promoter polymorphisms influence bilirubin response to hydroxyurea therapy in sickle cell anemia.

The Journal of laboratory and clinical medicine - 1 Apr 2003

Heeney Matthew M, Howard Thad A, Zimmerman Sherri A, Ware Russell E

Abstract excerpt

Hydroxyurea therapy reduces hemolysis and decreases serum bilirubin levels in children and adults with sickle cell anemia (SCA) and may therefore help prevent the development of cholelithiasis in this patient population. We recently reported that a promoter polymorphism in the uridine diphosphoglucuronate glucuronosyltransferase 1A (UGT1A) gene affects steady-state bilirubin levels and the incidence of gallstones...

Topics

Anemia, Sickle Cell
Antisickling Agents
Bilirubin
Child
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Genotype
Glucuronosyltransferase
Hemolysis
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydroxyurea

Male

Polymorphism, Genetic

Promoter Regions, Genetic

Reticulocyte Count

Retrospective Studies

Treatment Outcome

Source

Open in PubMed

Identifiers

PMID: 12677174
DOI: 10.1067/mlc.2003.28

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