Do Alpha Thalassemia, Fetal Hemoglobin, and the UGT1A1 Polymorphism have an Influence on Serum Bilirubin Levels and Cholelithiasis in Patients with Sickle Cell Disease?

doi:10.1007/s40291-017-0283-y

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Do Alpha Thalassemia, Fetal Hemoglobin, and the UGT1A1 Polymorphism have an Influence on Serum Bilirubin Levels and Cholelithiasis in Patients with Sickle Cell Disease?

Molecular diagnosis & therapy - 1 Aug 2017

de Azevedo Laura Alencastro, Bonazzoni Joyce, Wagner Sandrine Comparsi, Farias Mariela Granero, Bittar Christina M, Daudt Liane, de Castro Simone Martins

Abstract excerpt

BACKGROUND: Increased destruction of erythrocytes in patients with sickle cell disease results in chronic hyperbilirubinemia and leads to the formation of gallstones. OBJECTIVES: The objective of this study was to determine the combined influence of alpha thalassemia, fetal hemoglobin, and the UGT1A1 polymorphism on serum bilirubin levels and cholelithiasis in patients with sickle cell disease. METHODS: We...

Topics

Adolescent
Adult
Anemia, Sickle Cell
Bilirubin
Cholelithiasis
Female
Fetal Hemoglobin
Gene Expression
Genotype
Glucuronosyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Middle Aged

Polymorphism, Genetic

Promoter Regions, Genetic

alpha-Thalassemia

Source

Open in PubMed

Identifiers

PMID: 28567595
DOI: 10.1007/s40291-017-0283-y

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Do Alpha Thalassemia, Fetal Hemoglobin, and the UGT1A1 Polymorphism have an Influence on Serum Bilirubin Levels and Cholelithiasis in Patients with Sickle Cell Disease?PMID 28567595Read ↗

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