Article
[Relationship of epidermal growth factor receptor gene mutations, clinicopathologic features and prognosis in patients with non-small cell lung cancer].
Zhonghua bing li xue za zhi = Chinese journal of pathology - 1 Oct 2011
Fan Miao-jing, Li Hai-gang, Lü Zhi-qiang, Zhang Hui-zhong, Shen Xi-ming
Abstract excerpt
OBJECTIVE: To investigate epidermal growth factor receptor (EGFR) gene mutations in exons 19 and 21 of patients with non-small cell lung cancer (NSCLC) and to analyze the relationship of EGFR mutations with clinicopathological features and prognosis. METHODS: The EGFR gene exons 19 and 21 of paraffin-embedded tumor tissue were amplified by PCR, followed by direct sequencing in 282 surgically-removed specimens of...
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