Article
ADAM33 expression in asthmatic airways and human embryonic lungs.
American journal of respiratory and critical care medicine - 1 May 2005
Haitchi Hans Michael, Powell Robert M, Shaw Timothy J, Howarth Peter H, Wilson Susan J, Wilson David I, Holgate Stephen T, Davies Donna E
Abstract excerpt
RATIONALE: Polymorphic variation in ADAM33 (A Disintegrin And Metalloprotease) is strongly associated with asthma and bronchial hyperresponsiveness in different populations. OBJECTIVE AND METHODS: To study the role of ADAM33 in asthma, we investigated its expression in normal, asthmatic, and embryonic airways using reverse transcriptase-quantitative polymerase chain reaction and immunochemistry. RESULTS: Several...
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