Article
Human ADAM33: protein maturation and localization.
Biochemical and biophysical research communications - 31 Jan 2003
Garlisi Charles G, Zou Jun, Devito Kristine E, Tian Fang, Zhu Feng X, Liu Jianjun, Shah Himanshu, Wan Yuntao, Motasim Billah M, Egan Robert W, Umland Shelby P
Abstract excerpt
ADAM33 (a disintegrin and metalloprotease) was recently found to be a novel asthma susceptibility gene. Domain-specific antibodies were used to study its expression and processing. When the pro-domain and catalytic domain were expressed by a stable-transfected cell line, the pro-domain was removed by cleavage within a putative furin cleavage site. The catalytic domain was active in an alpha(2)-macroglobulin...
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