Article
The genetics of asthma: ADAM33 as an example of a susceptibility gene.
Proceedings of the American Thoracic Society - 1 Jul 2006
Holgate Stephen T, Yang Youwen, Haitchi Hans-Michael, Powell Rob M, Holloway John W, Yoshisue Hajime, Pang Yun Yun, Cakebread Julie, Davies Donna E
Abstract excerpt
The ability to identify novel disease genes by positional cloning led to the identification of a disintegrin and metalloprotease (ADAM)33 gene on chromosome 20p13 as a susceptibility gene for asthma. Case-control and family-based association studies have mostly confirmed a link between ADAM33 and asthma. Its restricted expression to mesenchymal cells as well as its association with bronchial hyperresponsiveness...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.