Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life

Abstract excerpt

Asthma is a chronic inflammatory airways disease that usually begins in early life and involves gene-environment interactions. Although most asthma exhibits allergic inflammation, many allergic individuals do not have asthma. Here, we report how the asthma gene a disintegrin and metalloprotease 33 ( ADAM33 ) acts as local tissue susceptibility gene that promotes allergic asthma. We show that enzymatically active...

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