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Article

RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor.

Cell reports - 31 May 2016

Sebestyen Zsolt, Scheper Wouter, Vyborova Anna, Gu Siyi, Rychnavska Zuzana, Schiffler Marleen, Cleven Astrid, Chéneau Coraline, van Noorden Martje, Peigné Cassie-Marie, Olive Daniel, Lebbink Robert Jan, Oostvogels Rimke, Mutis Tuna, Schuurhuis Gerrit Jan, Adams Erin J, Scotet Emmanuel, Kuball Jürgen

Abstract excerpt

Human Vγ9Vδ2 T cells respond to tumor cells by sensing elevated levels of phosphorylated intermediates of the dysregulated mevalonate pathway, which is translated into activating signals by the ubiquitously expressed butyrophilin A1 (BTN3A1) through yet unknown mechanisms. Here, we developed an unbiased, genome-wide screening method that identified RhoB as a critical mediator of Vγ9Vδ2 TCR activation in tumor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27210746
DOI: 10.1016/j.celrep.2016.04.081
PMCID: PMC5035041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor.PMID 27210746Read ↗

Phosphoantigen sensing combines TCR-dependent recognition of the BTN3A IgV domain and germline interaction with BTN2A1Semantic proximity Read ↗

A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human γδ T cell phosphoantigen sensingSemantic proximity Read ↗

The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells.Semantic proximity Read ↗

Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen SensingSemantic proximity Read ↗

Phosphoantigens are Molecular Glues that Promote Butyrophilin 3A1/2A1 Association Leading to Vγ9Vδ2 T Cell ActivationSemantic proximity Read ↗

Functional Phenotypes of Human Vγ9Vδ2 T Cells in Lymphoid Stress Surveillance.Semantic proximity Read ↗

BTN3A1 Discriminates γδ T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain.Semantic proximity Read ↗

Sensitivity to Vγ9Vδ2TCR T cells is imprinted after single mutations during early oncogenesisSemantic proximity Read ↗

Mutations to the BTN2A1 Linker Region Impact Its Homodimerization and Its Cytoplasmic Interaction with Phospho-Antigen-Bound BTN3A1.Semantic proximity Read ↗

Butyrophilin 2A2 promotes T cell immunoregulation by enhancing CD45 phosphatase activity within the immune synapseSemantic proximity Read ↗

γ9δ2 T-Cell Expansion and Phenotypic Profile Are Reflected in the CDR3δ Repertoire of Healthy Adults.Semantic proximity Read ↗

T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells.Semantic proximity Read ↗

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