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Article

Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival

11 Feb 2005

Abstract excerpt

The Akt kinases promote hematopoietic cell growth and accumulation through phosphorylation of apoptotic effectors and stimulation of mTOR-dependent translation. In Akt-transformed leukemic cells, tumor growth can be inhibited by the mTOR inhibitor rapamycin, and clinical trials of rapamycin analogs for the treatment of leukemia are under way. Surprisingly, nontransformed hematopoietic cells can grow and...

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Identifiers

PMID: 15705789
DOI: 10.1182/blood-2004-09-3706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survivalPMID 15705789Read ↗

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