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Article

Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice.

Journal of hematology & oncology - 29 Jan 2013

An Ningfei, Kraft Andrew S, Kang Yubin

Abstract excerpt

BACKGROUND: Pim (proviral insertion in murine lymphoma) kinases are a small family of constitutively active, highly conservative serine/threonine oncogenic kinases and have 3 members: Pim1, Pim2, and Pim3. Pim kinases are also implicated in the regulation of B- and T- cell responses to cytokines and hematopoietic growth factors. The roles of Pim kinases in the regulation of primitive hematopoietic stem cells...

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Identifiers

PMID: 23360755
DOI: 10.1186/1756-8722-6-12
PMCID: PMC3610283

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