Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging.

doi:10.18632/aging.100296

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Article

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging.

Aging - 1 Mar 2011

Steelman Linda S, Chappell William H, Abrams Stephen L, Kempf Ruth C, Long Jacquelyn, Laidler Piotr, Mijatovic Sanja, Maksimovic-Ivanic Danijela, Stivala Franca, Mazzarino Maria C, Donia Marco, Fagone Paolo, Malaponte Graziella, Nicoletti Ferdinando, Libra Massimo, Milella Michele, Tafuri Agostino, Bonati Antonio, Bäsecke Jörg, Cocco Lucio, Evangelisti Camilla, Martelli Alberto M, Montalto Giuseppe, Cervello Melchiorre, McCubrey James A

Abstract excerpt

Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation and decreased sensitivity to apoptotic-inducing agents are typically associated with activation of these pro-survival pathways. This review discusses the functions these pathways have in...

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PMID: 21422497
DOI: 10.18632/aging.100296
PMCID: PMC3091517

Genes

PTEN

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Source receipt: pubmed, retrieved 7 Sept 2026.

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