Article
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor.
Genes & development - 1 Aug 2003
Fox Casey J, Hammerman Peter S, Cinalli Ryan M, Master Stephen R, Chodosh Lewis A, Thompson Craig B
Abstract excerpt
Growth factor withdrawal results in the termination of factor-dependent transcription. One transcript that declines rapidly following growth factor deprivation of hematopoietic cells is the serine/threonine kinase pim-2. When constitutively expressed, Pim-2 conferred long-term resistance to a variety of apoptotic stimuli including growth factor withdrawal and endogenous levels of Pim-2 contributed to growth...
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