Article
Targeting PIM kinases impairs survival of hematopoietic cells transformed by kinase inhibitor-sensitive and kinase inhibitor-resistant forms of Fms-like tyrosine kinase 3 and BCR/ABL.
Cancer research - 1 Apr 2006
Adam Myriam, Pogacic Vanda, Bendit Marina, Chappuis Richard, Nawijn Martijn C, Duyster Justus, Fox Casey J, Thompson Craig B, Cools Jan, Schwaller Juerg
Abstract excerpt
Previous studies have shown that activation of the signal transducer and activator of transcription 5 (STAT5) plays an essential role in leukemogenesis mediated through constitutive activated protein tyrosine kinases (PTK). Because PIM-1 is a STAT5 target gene, we analyzed the role of the family of PIM serine/threonine kinases (PIM-1 to PIM-3) in PTK-mediated transformation of hematopoietic cells. Ba/F3 cells...
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