Article
Ligand-selective targeting of the glucocorticoid receptor to nuclear subdomains is associated with decreased receptor mobility.
Molecular endocrinology (Baltimore, Md.) - 1 Jun 2005
Schaaf Marcel J M, Lewis-Tuffin Laura J, Cidlowski John A
Abstract excerpt
The association between nuclear distribution and mobility of the human glucocorticoid receptor was examined in living COS-1 cells using yellow fluorescent protein- and cyan fluorescent protein-tagged receptors. Quantitation of the nuclear distribution induced by an array of glucocorticoid ligands revealed a continuum from a random (cortisone) to a nonrandom (triamcinolone acetonide) receptor distribution....
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