Article
Structure/function of the human glucocorticoid receptor: tyrosine 735 is important for transactivation.
Molecular endocrinology (Baltimore, Md.) - 1 Nov 1999
Ray D W, Suen C S, Brass A, Soden J, White A
Abstract excerpt
Ligand-induced activation of the glucocorticoid receptor (GR) is not well understood. The GR ligand-binding domain was modeled, based on homology with the progesterone receptor. Tyrosine 735 interacts with the D ring of dexamethasone, and substitution of D ring functional groups results in partial agonist steroids with reduced ability to direct transactivation. Loss of the Tyr735 hydroxyl group by substitution to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.