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Article

The recognition of nucleotides with model beta-hairpin receptors: investigation of critical contacts and nucleotide selectivity.

The Journal of organic chemistry - 18 Feb 2005

Butterfield Sara M, Sweeney Michelle M, Waters Marcey L

Abstract excerpt

[reaction: see text] We have investigated the factors that contribute to binding of ATP by a designed 12-residue beta-hairpin peptide, WKWK, and have determined its selectivity for binding to the naturally occurring nucleotide triphosphates. We have previously shown that WKWK creates an ATP binding pocket on one face of the beta-hairpin consisting of two Trp and two Lys residues. Mutation of the two Lys residues...

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Identifiers

PMID: 15704942
DOI: 10.1021/jo0491105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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