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Article

Conformational restraint is a critical determinant of unnatural nucleotide recognition by protein kinases.

Bioorganic & medicinal chemistry letters - 4 Nov 2002

Ulrich Scott M, Sallee Nathan A, Shokat Kevan M

Abstract excerpt

This report describes the synthesis of N(4)-(benzyl) AICAR triphosphate, a conformationally restrained analogue of N(4)-(benzyl) ribavirin triphosphate. Both of these nucleotides were evaluated as phosphodonors for wild-type p38MAP kinase and T106G p38MAP kinase, a designed mutant with expanded n...

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Identifiers

PMID: 12372539
DOI: 10.1016/s0960-894x(02)00616-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12372539-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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