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Article

A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src.

Bioorganic & medicinal chemistry - 1 Aug 1998

Liu Y, Shah K, Yang F, Witucki L, Shokat K M

Abstract excerpt

Engineered proteins with specificity for unnatural substrates or ligands are useful tools for studying or manipulating complex biological systems. We have engineered the prototypical tyrosine kinase v-Src to accept an unnatural ATP analogue N6-(benzyl) ATP in order to identify v-Src's direct cellular substrates. Here we have used molecular modeling to analyze the binding mode of N6-(benzyl) ATP. Based on this...

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PMID: 9784863
DOI: 10.1016/s0968-0896(98)00099-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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