Article
Solution structure of an ATP-binding RNA aptamer reveals a novel fold.
RNA (New York, N.Y.) - 1 Jul 1996
Dieckmann T, Suzuki E, Nakamura G K, Feigon J
Abstract excerpt
In vitro selection has been used to isolate several RNA aptamers that bind specifically to biological cofactors. A well-characterized example in the ATP-binding RNA aptamer family, which contains a conserved 11-base loop opposite a bulged G and flanked by regions of double-stranded RNA. The nucleotides in the consensus sequence provide a binding pocket for ATP (or AMP), which binds with a Kd in the micromolar...
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