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Article

Analysis of the interaction of the nucleotide base with myosin and the effect on substrate efficacy.

Biophysical journal - 7 Oct 2009

Hyatt David, Cooke Roger, Pate Edward

Abstract excerpt

A wide variety of purine- and pyrimidine-based nucleotides can serve as a substrate for actomyosin mechanics, but with varying effectiveness. To understand the myosin-ATP interaction and in particular, the interactions with the base, we have used molecular dynamics simulations to model the interactions of myosin with ATP, CTP, UTP, aza-ATP, ITP, and GTP (in decreasing order of effectiveness as a substrate for the...

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Identifiers

PMID: 19804726
DOI: 10.1016/j.bpj.2009.07.022
PMCID: PMC2756361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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