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Article

Determinants of homocysteine-thiolactonase activity of the paraoxonase-1 (PON1) protein in humans.

Cellular and molecular biology (Noisy-le-Grand, France) - 1 Dec 2004

Lacinski M, Skorupski W, Cieslinski A, Sokolowska J, Trzeciak W H, Jakubowski H

Abstract excerpt

Homocysteine (Hcy)-thiolactonase (HTase) activity of the paraoxonase-1 (PON1) protein detoxifies Hcy-thiolactone in human blood and could thus delay the development of atherosclerosis. To gain insight into physiological role(s) of the PON1 protein, we studied HTase activities and PON1 genotypes in a group of 184 subjects, 32.6% of whom were healthy, 27.7% had angiographically proven coronary artery disease but...

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Identifiers

PMID: 15704252

Genes

PON1
CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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