Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discovery of a novel homocysteine thiolactone hydrolase and the catalytic activity of its natural variants.

Protein science : a publication of the Protein Society - 1 Aug 2024

Hou Shurong, Liu Huan, Hu Yihui, Zhang Jie, Deng Xingyu, Li Zhenzhen, Zhang Yun, Li Xiaoxuan, Li Yishuang, Ma Lei, Yao Jianzhuang, Chen Xiabin

Abstract excerpt

Homocysteine thiolactone (HTL), a toxic metabolite of homocysteine (Hcy) in hyperhomocysteinemia (HHcy), is known to modify protein structure and function, leading to protein damage through formation of N-Hcy-protein. HTL has been highly linked to HHcy-associated cardiovascular and neurodegenerative diseases. The protective role of HTL hydrolases against HTL-associated vascular toxicity and neurotoxicity have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carboxylic Ester Hydrolases
Share to Homocysteine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kinetics

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 38980003
DOI: 10.1002/pro.5098
PMCID: PMC11232049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovery of a novel homocysteine thiolactone hydrolase and the catalytic activity of its natural variants.PMID 38980003Read ↗

Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase.Semantic proximity Read ↗

Homocysteine Thiolactone Detoxifying Enzymes and Alzheimer’s DiseaseSemantic proximity Read ↗

Discovery of a new function of human butyrylcholinesterase and the catalytic activity of its natural variants toward homocysteine thiolactone hydrolysisSemantic proximity Read ↗

Homocysteine Metabolites, Endothelial Dysfunction, and Cardiovascular DiseaseSemantic proximity Read ↗

Phosphatase activity of soluble epoxide hydrolase.Semantic proximity Read ↗

Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1.Semantic proximity Read ↗

Determinants of homocysteine-thiolactonase activity of the paraoxonase-1 (PON1) protein in humans.Semantic proximity Read ↗

Major implications of single nucleotide polymorphisms in human carboxylesterase 1 on substrate bioavailability.Semantic proximity Read ↗

Mechanism-based inhibition of human persulfide dioxygenase by γ-glutamyl-homocysteinyl-glycine.Semantic proximity Read ↗

Understanding the Impact of Mutations in the Cystathionine Beta-Synthase Gene: Towards Novel Therapeutics for Homocystinuria.Semantic proximity Read ↗

Genetic determinants of homocysteine thiolactonase activity in humans: implications for atherosclerosis.Semantic proximity Read ↗

Structural insights into the catalytic mechanism of lovastatin hydrolase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.