CD44/PI3K/NF-κB/AHR is a Novel Signaling Pathway Mediating Breast Tumor Progression

Abstract excerpt

<title>Abstract</title> <p>Cell adhesion molecules (CAMs), present on cell surfaces, are involved in cell-to-cell and cell-extracellular adhesion. The hyaluronic acid (HA) receptor, CD44, is a CAM protein that is highly generally highly expressed in metastatic solid tumors, including breast cancer (BC), and correlates with poor prognosis. To increase our understanding of the underlying CD44-downstream signaling p...

Topics

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• Conserved Sequence
• Gene Knockdown Techniques
• Genes, Reporter
• Hyaluronan Receptors
• NF-kappa B
• Organ Specificity
• Regulatory Sequences, Nucleic Acid
• Transcription Factor AP-1

Identifiers and source

Literature Corpus work

86041328-fbfe-5937-a4d1-43c98a7438fd

DOI

10.21203/rs.3.rs-4262195/v1