Article
Thyroid hormone direct repeat 4 response element is a positive regulatory element for the human TR2 orphan receptor, a member of steroid receptor superfamily.
Molecular and cellular biochemistry - 1 Dec 1998
Chang C, Pan H J
Abstract excerpt
We demonstrate that TR2 orphan receptor (TR2) may induce transactivation activities via an AGGTCA-like-direct-repeat-4 consensus thyroid hormone response element (DR4-TRE) system. TR2 showed a slightly greater binding affinity than thyroid hormone receptor alpha1 (TR alpha1)/retinoid X receptor a...
Topics
- Carrier Proteins
- Chloramphenicol O-Acetyltransferase
- Electrophoresis, Gel, Two-Dimensional
- Humans
- In Vitro Techniques
- Mutation
- Nerve Tissue Proteins
- Nuclear Receptor Subfamily 2, Group C, Member 1
- Plasmids
- Receptors, Steroid
- Receptors, Thyroid Hormone
- Response Elements
- Thyroid Hormones
- Transfection