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Article

Genetic predisposition in patients with hypertension and normal ejection fraction to oxidative stress.

Journal of the American Society of Hypertension : JASH - 1 Feb 2016

Fazakas Ádám, Szelényi Zsuzsanna, Szénási Gábor, Nyírő Gábor, Szabó Péter M, Patócs Attila, Tegze Narcis, Fekete Bertalan C, Molvarec Attila, Nagy Bálint, Jakus Judit, Örsi Ferenc, Karádi István, Vereckei András

Abstract excerpt

The role of oxidative stress (OXS) due to myocardial nitric oxide synthase (NOS) uncoupling related to oxidative depletion of its cofactor tetrahydrobiopterin (BH4) emerged in the pathogenesis of heart failure with preserved ejection fraction. We determined the prevalence of six single nucleotide polymorphisms (SNPs) of genes encoding enzymes related to OXS, BH4 metabolism, and NOS function in ≥60-year-old 94...

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Identifiers

PMID: 26778769
DOI: 10.1016/j.jash.2015.11.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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