Article
Glutathione S-transferase variants and hypertension.
Journal of hypertension - 1 Jul 2008
Delles Christian, Padmanabhan Sandosh, Lee Wai Kwong, Miller William H, McBride Martin W, McClure John D, Brain Nick J, Wallace Chris, Marçano Ana C B, Schmieder Roland E, Brown Morris J, Caulfield Mark J, Munroe Patricia B, Farrall Martin, Webster John, Connell John M, Dominiczak Anna F
Abstract excerpt
OBJECTIVES: Glutathione S-transferases are involved in defences against oxidative stress. We have recently demonstrated reduced expression of glutathione S-transferase mu type 1 (Gstm1) in a rat model of hypertension. Here, we examine the association between GSTM variants and hypertension in human. METHODS: We screened 83 patients with hypertension and 46 controls for single nucleotide polymorphisms in GSTM genes...
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