Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease.

doi:10.1161/JAHA.115.002701

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Article

Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease.

Journal of the American Heart Association - 17 Feb 2016

Rubattu Speranza, Di Castro Sara, Schulz Herbert, Geurts Aron M, Cotugno Maria, Bianchi Franca, Maatz Henrike, Hummel Oliver, Falak Samreen, Stanzione Rosita, Marchitti Simona, Scarpino Stefania, Giusti Betti, Kura Ada, Gensini Gian Franco, Peyvandi Flora, Mannucci Pier Mannuccio, Rasura Maurizia, Sciarretta Sebastiano, Dwinell Melinda R, Hubner Norbert, Volpe Massimo

Abstract excerpt

BACKGROUND: The genetic basis of stroke susceptibility remains to be elucidated. STR1 quantitative trait locus (STR1/QTL) was identified on rat chromosome 1 of stroke-prone spontaneously hypertensive rat (SHRSP) upon Japanese-style stroke-permissive diet (JD), and it contributes to 20% of the stroke phenotype variance. METHODS AND RESULTS: Nine hundred eighty-six probe sets mapping on STR1 were selected from the...

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PMID: 26888427
DOI: 10.1161/JAHA.115.002701
PMCID: PMC4802485

Genes

NDUFC2

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