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Article

Equilibrium unfolding of neuronal calcium sensor-1: N-terminal myristoylation influences unfolding and reduces protein stiffening in the presence of calcium.

The Journal of biological chemistry - 22 Apr 2005

Muralidhar Dasari, Jobby Maroor K, Krishnan Kannan, Annapurna Vallabhaneni, Chary Kandala V R, Jeromin Andreas, Sharma Yogendra

Abstract excerpt

Neuronal calcium sensor-1 (NCS-1), a Ca(2+)-binding protein of the calcium sensor family, modulates various functions in intracellular signaling pathways. The N-terminal glycine in this protein is myristoylated, which is presumably necessary for its physiological functions. In order to understand the structural role of myristoylation and calcium on conformational stability, we have investigated the equilibrium...

Topics

Amino Acid Substitution
Animals
Calcium
Calcium-Binding Proteins
Guanidine
Mutation
Myristic Acid
Neuronal Calcium-Sensor Proteins
Neuropeptides
Protein Denaturation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Spectrometry, Fluorescence

Trypsin

Tryptophan

Source

Identifiers

PMID: 15699030
DOI: 10.1074/jbc.M414243200

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