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Article

Lipid-mediated folding/unfolding of phospholamban as a regulatory mechanism for the sarcoplasmic reticulum Ca2+-ATPase.

Journal of molecular biology - 13 May 2011

Gustavsson Martin, Traaseth Nathaniel J, Karim Christine B, Lockamy Elizabeth L, Thomas David D, Veglia Gianluigi

Abstract excerpt

The integral membrane protein complex between phospholamban (PLN) and sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) regulates cardiac contractility. In the unphosphorylated form, PLN binds SERCA and inhibits Ca(2+) flux. Upon phosphorylation of PLN at Ser16, the inhibitory effect is reversed. Although structural details on both proteins are emerging from X-ray crystallography, cryo-electron microscopy, and NMR...

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Source

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Identifiers

PMID: 21419777
DOI: 10.1016/j.jmb.2011.03.015
PMCID: PMC3573877

Genes

PLN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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