Article
Calcium-dependent cysteine reactivities in the neuronal calcium sensor guanylate cyclase-activating protein 1.
FEBS letters - 23 Nov 2001
Hwang J Y, Schlesinger R, Koch K W
Abstract excerpt
Guanylate cyclase-activating protein 1 (GCAP-1) is a Ca(2+)-sensing protein in vertebrate photoreceptor cells. It activates a membrane-bound guanylate cyclase. Three of four cysteines present in wild-type GCAP-1 were accessible to the thiol-modifying reagent 5,5'-dithio-bis-(2-nitrobenzoic acid) in the presence of Ca(2+). Only Cys106 became exposed to the solvent after Ca(2+)-chelation. Since Cys106 is located in...
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