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Article

A highly conserved cysteine of neuronal calcium-sensing proteins controls cooperative binding of Ca2+ to recoverin.

The Journal of biological chemistry - 13 Dec 2013

Ranaghan Matthew J, Kumar Ramasamy P, Chakrabarti Kalyan S, Buosi Vanessa, Kern Dorothee, Oprian Daniel D

Abstract excerpt

Recoverin, a 23-kDa Ca(2+)-binding protein of the neuronal calcium sensing (NCS) family, inhibits rhodopsin kinase, a Ser/Thr kinase responsible for termination of photoactivated rhodopsin in rod photoreceptor cells. Recoverin has two functional EF hands and a myristoylated N terminus. The myristoyl chain imparts cooperativity to the Ca(2+)-binding sites through an allosteric mechanism involving a conformational...

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Identifiers

PMID: 24189072
DOI: 10.1074/jbc.M113.524355
PMCID: PMC3861663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A highly conserved cysteine of neuronal calcium-sensing proteins controls cooperative binding of Ca2+ to recoverin.PMID 24189072Read ↗

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Structure and calcium-binding studies of a recoverin mutant (E85Q) in an allosteric intermediate state.Semantic proximity Read ↗

Recoverin binds exclusively to an amphipathic peptide at the N terminus of rhodopsin kinase, inhibiting rhodopsin phosphorylation without affecting catalytic activity of the kinase.Semantic proximity Read ↗

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