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Article

Population genetics of CAPN10 and GPR35: implications for the evolution of type 2 diabetes variants.

American journal of human genetics - 1 Apr 2005

Vander Molen J, Frisse L M, Fullerton S M, Qian Y, Del Bosque-Plata L, Hudson R R, Di Rienzo A

Abstract excerpt

A positional cloning study of type 2 diabetes in Mexican Americans identified a region, termed "NIDDM1," on chromosome 2q37 with significant linkage evidence. Haplotype combinations at the calpain-10 gene (CAPN10) within this region were shown to increase diabetes risk in several populations. On the basis of the thrifty genotype hypothesis, variants that increase susceptibility to type 2 diabetes under modern...

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Share to Calpain
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Mexican Americans

Share to Models, Genetic

Share to Polymorphism, Genetic

Share to Receptors, G-Protein-Coupled

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 15696418
DOI: 10.1086/428784
PMCID: PMC1199293

Genes

CAPN10
GPR35

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Population genetics of CAPN10 and GPR35: implications for the evolution of type 2 diabetes variants.PMID 15696418Read ↗

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