Article
Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians.
The Journal of clinical endocrinology and metabolism - 1 Feb 2002
Elbein Steven C, Chu Winston, Ren Qianfang, Hemphill Chris, Schay John, Cox Nancy J, Hanis Craig L, Hasstedt Sandra J
Abstract excerpt
The calpain-10 gene (CAPN10) has been implicated in type 2 diabetes (T2DM) susceptibility by both linkage and association in a Hispanic population from Starr County Texas. Common intronic variants seem to alter CAPN10 mRNA levels and were associated with insulin resistance but not diabetes in Pima Indians. The role of these variants in Caucasian populations is less clear. We found some evidence for linkage of...
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