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Article

Haplotype structure and phylogenetic shadowing of a hypervariable region in the CAPN10 gene.

Human genetics - 1 Jul 2005

Clark Vanessa J, Cox Nancy J, Hammond Molly, Hanis Craig L, Di Rienzo Anna

Abstract excerpt

It has been proposed that variation in calpain 10 (CAPN10) contributes to the risk of type 2 diabetes (T2D). A previous survey of CAPN10 in ethnically diverse populations revealed an intronic region with a significant excess of polymorphism levels relative to inter-species sequence divergence, suggesting that this region was the target of long-standing balancing selection. Based on the thrifty genotype...

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Share to Calpain
Share to Diabetes Mellitus, Type 2
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Phylogeny

Share to Polymorphism, Single Nucleotide

Share to Primates

Share to Selection, Genetic

Source

Identifiers

PMID: 15906097
DOI: 10.1007/s00439-005-1305-0

Genes

CAPN10

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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