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Article

Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism - 1 Jun 2002

Haddad Lema, Evans Julie C, Gharani Neda, Robertson Carole, Rush Karen, Wiltshire Steven, Frayling Timothy M, Wilkin Terence J, Demaine Andrew, Millward Ann, Hattersley Andrew T, Conway Gerry, Cox Nancy J, Bell Graeme I, Franks Steve, McCarthy Mark I

Abstract excerpt

Variation within the calpain-10 gene (CAPN10) has been proposed to account for linkage to type 2 diabetes on chromosome 2q in Mexican-Americans, and associations with diabetes have been reported in several other populations. Given the epidemiological, physiological, and genetic overlap between type 2 diabetes and polycystic ovary syndrome (PCOS), CAPN10 represents a strong candidate gene for a role in PCOS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Mapping

Share to Diabetes Mellitus, Type 2

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Share to Quantitative Trait, Heritable

Source

Identifiers

PMID: 12050223
DOI: 10.1210/jcem.87.6.8608

Genes

CAPN10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome.PMID 12050223Read ↗

Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom.Semantic proximity Read ↗

Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians.Semantic proximity Read ↗

Type 2 diabetes candidate gene CAPN10: first, but not last.Semantic proximity Read ↗

111/121 diplotype of Calpain-10 is associated with the risk of polycystic ovary syndrome in Korean women.Semantic proximity Read ↗

Common polymorphisms of calpain-10 and the risk of polycystic ovary syndrome in Tunisian population: a case-control study.Semantic proximity Read ↗

Association of the calpain-10 gene with type 2 diabetes mellitus in a Mexican population.Semantic proximity Read ↗

Common genetic variation in calpain-10 gene (CAPN10) and diabetes risk in a multi-ethnic cohort of American postmenopausal women.Semantic proximity Read ↗

Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians.Semantic proximity Read ↗

Association between CAPN10 UCSNP-43 gene polymorphism and polycystic ovary syndrome in Chilean women.Semantic proximity Read ↗

Calpain-10 variants and haplotypes are associated with polycystic ovary syndrome in Caucasians.Semantic proximity Read ↗

Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association.Semantic proximity Read ↗

Variants in the calpain-10 gene predispose to insulin resistance and elevated free fatty acid levels.Semantic proximity Read ↗

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