Article
Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus.
American journal of human genetics - 1 May 2002
Fullerton Stephanie M, Bartoszewicz Angelika, Ybazeta Gustavo, Horikawa Yukio, Bell Graeme I, Kidd Kenneth K, Cox Nancy J, Hudson Richard R, Di Rienzo Anna
Abstract excerpt
Recently, a positional cloning study proposed that haplotypes at the calpain-10 locus (CAPN10) are associated with increased risk of type 2 diabetes, or non-insulin-dependent diabetes mellitus, in Mexican Americans, Finns, and Germans. To inform the interpretation of the original mapping results and to look for evidence for the action of natural selection on CAPN10, we undertook a population-based genotyping...
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