Article
Acute LPS inhalation in healthy volunteers induces dendritic cell maturation in vivo.
The Journal of allergy and clinical immunology - 1 Feb 2005
Alexis Neil E, Lay John C, Almond Martha, Bromberg Philip A, Patel Dhavalkumar D, Peden David B
Abstract excerpt
BACKGROUND: We have been studying the innate immune response of airways cells of healthy human volunteers to inhaled LPS, a Toll-like receptor 4 (TLR4) ligand, and have shown that macrophage phagocytic capacity is blunted. OBJECTIVE: Because a primary feature of dendritic cell (DC) maturation is a loss of phagocytic capacity, we sought to determine whether acute LPS inhalation in healthy volunteers promotes DC...
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