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Article

Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2002

Dabbagh Karim, Dahl Martin E, Stepick-Biek Pamela, Lewis David B

Abstract excerpt

LPS potently induces dendritic cell maturation and the production of proinflammatory cytokines, such as IL-12, by activation of Toll-like receptor 4 (TLR4). Since IL-12 is important for the generation and maintenance of Th1 responses and may also inhibit Th2 cell generation from naive CD4 T cell precursors, it has been inferred that TLR4 signaling would have similar effects via the induction of IL-12 secretion....

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Source

Identifiers

PMID: 11970998
DOI: 10.4049/jimmunol.168.9.4524

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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