Article
Gender, smoking, glutathione-S-transferase variants and bladder cancer incidence: a population-based study.
Cancer letters - 28 Feb 2005
Karagas Margaret R, Park Sunyeong, Warren Amy, Hamilton Joshua, Nelson Heather H, Mott Leila A, Kelsey Karl T
Abstract excerpt
OBJECTIVE: Male gender, tobacco smoking and occupational exposure to arylamines and polycyclic aromatic hydrocarbons are the primary risk factors for bladder cancer. Emerging, and consistent data indicate that risk may be modified by polymorphisms in carcinogen metabolism genes, including those involving the glutathione-S-transferases. Recent work further suggests that susceptibility to the carcinogenic effects...
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