Article
GSTA1, GSTM1, GSTP1, and GSTT1 polymorphisms and susceptibility to smoking-related bladder cancer: a case-control study.
Urologic oncology - 1 Oct 2013
Matic Marija, Pekmezovic Tatjana, Djukic Tatjana, Mimic-Oka Jasmina, Dragicevic Dejan, Krivic Biljana, Suvakov Sonja, Savic-Radojevic Ana, Pljesa-Ercegovac Marija, Tulic Cane, Coric Vesna, Simic Tatjana
Abstract excerpt
OBJECTIVES: Glutathione S-transferases (GSTs) are a family of enzymes involved in detoxification. Genes encoding for GSTA1, GSTM1, GSTP1, and GSTT1 proteins are polymorphic, which can result in complete or partial loss of enzyme activity. Previous studies have associated polymorphisms of GSTA1, GSTM1, and GSTP1 genes with a higher risk of bladder cancer, but this is still controversial. Potential role of GSTA1...
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