Article
Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review.
American journal of epidemiology - 15 Jul 2002
Engel Lawrence S, Taioli Emanuela, Pfeiffer Ruth, Garcia-Closas Montserrat, Marcus Pamela M, Lan Qing, Boffetta Paolo, Vineis Paolo, Autrup Herman, Bell Douglas A, Branch Robert A, Brockmöller Jürgen, Daly Ann K, Heckbert Susan R, Kalina Ivan, Kang Daehee, Katoh Takahiko, Lafuente Amalia, Lin Henry J, Romkes Marjorie, Taylor Jack A, Rothman Nathaniel
Abstract excerpt
Smoking is a known risk factor for bladder cancer. The product of the GSTM1 gene, glutathione S-transferase M1 (GSTM1), is involved in the detoxification of polycyclic aromatic hydrocarbons found in tobacco smoke; a homozygous deletion of this gene in approximately 50% of Caucasians and Asians results in a lack of GSTM1 enzyme activity. Most studies examining the relation between bladder cancer and GSTM1 have...
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