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Article

A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder.

Neuroscience letters - 23 Jan 2004

Benedetti Francesco, Bernasconi Alessandro, Lorenzi Cristina, Pontiggia Adriana, Serretti Alessandro, Colombo Cristina, Smeraldi Enrico

Abstract excerpt

Genetic studies in medicine exploited age of onset as a criterion to delineate subgroups of illness. Bipolar patients stratified with this criterion were shown to share clinical characteristics and patterns of inheritance of illness. The molecular mechanisms driving the biological clock in the suprachiasmatic nucleus of the hypothalamus may play a role in mood disorders. A single nucleotide polymorphism (SNP)...

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PMID: 14729229
DOI: 10.1016/j.neulet.2003.10.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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