Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

VH gene analysis of primary CNS lymphomas.

Journal of the neurological sciences - 15 Feb 2005

Pels Hendrik, Montesinos-Rongen Manuel, Schaller Carlo, Schlegel Uwe, Schmidt-Wolf Ingo G H, Wiestler Otmar D, Deckert Martina

Abstract excerpt

Primary CNS lymphomas (PCNSL) are highly malignant non-Hodgkin's lymphomas of B cell origin associated with a poor prognosis. These neoplasms show variable sensitivity to radio- and chemotherapy. A molecular basis for these differences in treatment responses has not yet been established for primary CNS lymphomas in a comprehensive series of patients. Here, we performed PCR analyses of the immunoglobulin (Ig) gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Gene Rearrangement, B-Lymphocyte

Share to Genes, Immunoglobulin

Share to Immunoglobulins

Share to Lymphoma, Non-Hodgkin

Share to Predictive Value of Tests

Source

Identifiers

PMID: 15694195
DOI: 10.1016/j.jns.2004.11.038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

VH gene analysis of primary CNS lymphomas.PMID 15694195Read ↗

Immunoglobulin Repertoire of Primary Lymphomas of the Central Nervous SystemSemantic proximity Read ↗

Primary central nervous system lymphomas express Vh genes with intermediate to high somatic mutations.Semantic proximity Read ↗

Primary central nervous system lymphomas are derived from germinal-center B cells and show a preferential usage of the V4-34 gene segment.Semantic proximity Read ↗

Primary malignant lymphoma of the brain: mutation pattern of rearranged immunoglobulin heavy chain gene.Semantic proximity Read ↗

Limited detection of IgH gene rearrangements in plasma of patients with primary central nervous system lymphomaSemantic proximity Read ↗

Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status.Semantic proximity Read ↗

V(H) gene sequences from primary central nervous system lymphomas indicate derivation from highly mutated germinal center B cells with ongoing mutational activity.Semantic proximity Read ↗

Molecular Analysis of Immunoglobulin Genes in Primary Intraocular LymphomaSemantic proximity Read ↗

Lack of BRAF V600E protein expression in primary central nervous system lymphoma.Semantic proximity Read ↗

Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity.Semantic proximity Read ↗

Primary malignant lymphoma of the brain: frequent abnormalities and inactivation of p14 tumor suppressor gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.