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Article

Molecular Analysis of Immunoglobulin Genes in Primary Intraocular Lymphoma

26 Sept 2005

Abstract excerpt

PURPOSE: To analyze somatic hypermutations in clonally rearranged IgH chain variable (V) genes of primary intraocular lymphoma (PIOL), to identify the differentiation stage of B-PIOL cells. METHODS: Sixteen cases of PIOL were diagnosed on the basis of morphology and immunohistology. In six patients, simultaneous cerebral lymphomatous involvement was known; stereotactic biopsy specimens were investigated in three...

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PMID: 16186327
DOI: 10.1167/iovs.05-0401

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