Article
[Mutation, loss of heterozygosity, and expression of tumor suppressor gene ING1 in sporadic colorectal carcinoma].
Ai zheng = Aizheng = Chinese journal of cancer - 1 Feb 2005
Wei Jian-Bao, Chen Li-Sheng, Gao Feng
Abstract excerpt
BACKGROUND & OBJECTIVE: Inhibitor of growth 1 (ING(1)) gene has been identified as a novel tumor suppressor gene. Its over-expression can inhibit cell growth, and induce cell apoptosis. This study was to explore the effect and significance of ING(1) gene in occurrence and progression of sporadic colorectal cancer. METHODS: The expression, mutation, and loss of heterozygosity (LOH) of ING(1) gene in 46 specimens...
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