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Article

Osteoporosis induced in mice by overproduction of interleukin 4.

15 Dec 1993

Abstract excerpt

Osteoporosis is a common disease in which loss of bone mass results in skeletal fragility. The development of therapies for this disorder has been hampered by the lack of a convenient animal model. Here we describe a disorder in bone homeostasis in transgenic mice that inappropriately express the cytokine interleukin 4 (IL-4) under the direction of the lymphocyte-specific proximal promoter for the lck gene. Bone...

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PMID: 8265598
DOI: 10.1073/pnas.90.24.11618

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